
Assassin's Creed: Brotherhood has 4 confirmed real-world locations in Italy and Vatican City.

Borgia stronghold
Cesare Borgia holds Rome from the papal fortress linked to the Vatican by a passage.
Castel Sant'Angelo
as Rome

Lair of Romulus
Ezio infiltrates a sealed chamber beneath the Pantheon during the Romulus cult quests.
Pantheon
as Rome

Roman underground
Ezio descends beneath the arena to destroy a Borgia war machine.
Colosseum
as Rome

Vatican finale
Ezio confronts Cesare Borgia as the Brotherhood reclaims Rome.
St. Peter's Square
as Vatican
Community posts
Real-world locations FAQ
Where is Assassin's Creed: Brotherhood set?
Assassin's Creed: Brotherhood has 4 confirmed real-world locations in Italy and Vatican City that inspired or stand in for places in the game. Use the map and location list below for addresses, coordinates, and scene-by-scene details.
Can you visit these real-world locations?
Many are public streets, landmarks, or businesses you can visit in real life—even when the game renames or reimagines them. Each location page notes access where we know it, and the community shares photos from real visits.
